Does Sertraline Cause Hair Loss? Understanding the Connection

Sertraline (Zoloft) is a widely prescribed SSRI antidepressant effective for depression, anxiety, and OCD. However, some users report unexpected hair thinning while on the medication. If you’re asking “Does sertraline cause hair loss?”, you’re not alone. This article examines the scientific evidence, explains why this side effect occurs, and provides solutions to protect your hair.

Table of Contents

• The Link Between Sertraline and Hair Loss: What Research Says
  • Is Hair Loss a Documented Side Effect?
  • Why Might Sertraline Cause Hair Loss?
• Identifying Sertraline-Related Hair Loss
  • Signs to Watch For:
• Managing Hair Loss While on Sertraline
  • 1. Talk to Your Doctor
  • 2. Hair-Strengthening Strategies
  • 3. Nutritional Support
• Good News: Hair Usually Grows Back
• When to Seek Help
• Final Verdict: Does Sertraline Cause Hair Loss?

The Link Between Sertraline and Hair Loss: What Research Says

Is Hair Loss a Documented Side Effect?

• The FDA lists alopecia (hair loss) as a rare side effect of sertraline (<1% of users)
• A 2018 study in Journal of Clinical Psychiatry found SSRIs (including sertraline) may trigger telogen effluvium (temporary shedding)
• Unlike chemotherapy-induced hair loss, sertraline-related thinning is typically mild and reversible

Why Might Sertraline Cause Hair Loss?

1. Stress on Hair Follicles

• SSRIs alter serotonin levels, which may disrupt the hair growth cycle
• Can push more hairs into the telogen (resting) phase → increased shedding

1. Nutritional Factors

• Sertraline may affect appetite, leading to deficiencies in iron, zinc, or biotin (vital for hair health)

1. Hormonal Changes

• Some users report changes in thyroid function or androgen levels while on SSRIs

Identifying Sertraline-Related Hair Loss

Signs to Watch For:

✔ Increased hair in your brush/shower drain
✔ Overall thinning (not just at the hairline)
✔ Shedding begins 2-4 months after starting sertraline

Note: Diffuse thinning (all over) suggests telogen effluvium, while patchy loss may indicate another condition like alopecia areata.

Managing Hair Loss While on Sertraline

1. Talk to Your Doctor

• Rule out other causes (thyroid issues, anemia)
• Ask about:
• Lowering your dose
• Switching to another SSRI (e.g., fluoxetine has lower reported hair loss risk)

2. Hair-Strengthening Strategies

Solution	How It Helps
Minoxidil (Rogaine)	Stimulates follicles, counters shedding
Biotin & Collagen Supplements	Supports keratin production
Gentle Hair Care	Avoid heat styling, tight ponytails
Stress Reduction	Yoga/meditation to complement SSRI effects

3. Nutritional Support

• Iron-rich foods: Spinach, lentils (low iron worsens shedding)
• Omega-3s: Salmon, walnuts (reduce inflammation)
• Vitamin D: Eggs, fortified milk (linked to hair follicle health)

Good News: Hair Usually Grows Back

• If sertraline is the cause, shedding typically stops within 6 months of discontinuation
• For those who stay on the medication, hair often adapts and regrows with proper care

When to Seek Help

Consult a dermatologist if:

• Shedding persists beyond 6 months
• You notice bald patches or scalp irritation
• Hair loss is severely impacting your self-esteem

Final Verdict: Does Sertraline Cause Hair Loss?

✅ Yes, but rarely – Affects a small percentage of users, usually temporarily.
⚠ Manageable – Most cases improve with targeted treatments without quitting medication.
❌ Not permanent – Unlike genetic hair loss, SSRI-related thinning often reverses.

Key Takeaway: Don’t stop sertraline abruptly—work with your doctor to find a balanced solution.

Did sertraline affect your hair? Share your experience in the comments!